Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients

Yokota, Takashi
Kinugawa, Shintaro
Hirabayashi, Kagami
Yamato, Mayumi
Takada, Shingo
Suga, Tadashi
Nakano, Ippei
Fukushima, Arata
Matsushima, Shouji
Okita, Koichi
Tsutsui, Hiroyuki

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Publication date

January 2021

DOI

10.1038/s41598-021-81736-0

Publisher

Springer Science and Business Media LLC

Abstract

Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 +/- 1.1 vs. 3.4 +/- 0.7 mu mol/L, p7.1 vs. 29.4 +/- 9.7 units/L, p<0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the paramete...