Curcumin Loaded PEGylated Nanoemulsions Designed for Maintained Antioxidant Effects and Improved Bioavailability: A Pilot Study on Rats
- Jelena B. Đoković
- Sanela M. Savić
- Jelena R. Mitrović
- Ines Nikolic
- Bojan D. Marković
- Danijela V. Randjelović
- Jelena Antic-Stankovic
- Dragana Božić
- Nebojša D. Cekić
- Vladimir Stevanović
- Bojan Batinić
- Jovana Aranđelović
- Miroslav M. Savić
- Snežana D. Savić
DOIAbstract
The current study describes the experimental design guided development of PEGylated nanoemulsions as parenteral delivery systems for curcumin, a powerful antioxidant, as well as the evaluation of their physicochemical characteristics and antioxidant activity during the two years of storage. Experimental design setup helped development of nanoemulsion templates with critical quality attributes in line with parenteral application route. Curcumin-loaded nanoemulsions showed mean droplet size about 105 nm, polydispersity index <0.15, zeta potential of −40 mV, and acceptable osmolality of about 550 mOsm/kg. After two years of storage at room temperature, all formulations remained stable. Moreover, antioxidant activity remained intact, as demonst...
.jpg%3Fwidth%3D300&w=3840&q=75)
_alternate.svg%3Fwidth%3D300&w=3840&q=75)
.jpg%3Fwidth%3D300&w=3840&q=75)
Add to ORKG