Tumour imaging using hCG-specific monoclonal antibodies

The aim of this thesis was to radiolabel two different anti-hCG antibodies with 111-indium, and to determine their specific tumour uptake and tissue biodistribution into choriocarcinoma xenografts in nude mice against 111-indium and 67-gallium citrate over 72 hours. Comparative radioimmunoscintigraphy was performed to determine the optimal imaging post injection for visualisation of tumour sites. Data manipulation using dual isotope computerised subtraction in mouse phantom models was evaluated as means of improving tumour delineation in low tumour contrast studies