Auswirkungen von unterschiedlichen Zahncremes mit verschiedenen Fluoridverbindungen auf demineralisierten Schmelzproben in vitro

Objectives: The aim of this study was to compare the caries preventive effect of a stabilized stannous fluoride/sodium fluoride dentifrice containing sodium hexametaphosphate with those of a regular, solely sodium fluoride-containing and amine fluoride-containing dentifrice on pre-demineralized bovine enamel specimens using a pH-cycling model. Methods: Bovine enamel specimens with two artificial lesions each were prepared. Baseline mineral loss of both lesions was analyzed using transversal microradiography (TMR). Eighty-five specimens with a mean (SD) baseline mineral loss of 3,393 (683) vol%×µm were selected and randomly allocated to five groups (n=13/15). Treatments during pH-cycling (28days and 2×20min demineralization/day) were: brushing twice daily with slurries of: AmF (1,400ppm F-), NaF (1,450ppm F-), SnF2/NaF (1,100ppm F-/350ppm F-), and fluoride-free (FF) dentifrices or they were immersed in distilled water und remained unbrushed (NB). Subsequently, from each specimen one lesion was covered with acid resistant varnish, while the remaining lesion was demineralized for another 14days. Differences in integrated mineral loss (∆∆Z) were calculated between values before and after pH-cycling (∆∆ZE1) as well as before pH-cycling and after second demineralization (∆∆ZE2) using TMR. Results: Treatments AmF and NaF induced a significantly higher mineral gain (∆∆ZE1/∆∆ZE2) compared to treatments FF and NB (p<0.05;ANOVA-test). Except for treatments AmF and NaF no significant differences in mineral loss between before and after pH-cycling could be observed (p