Add to ORKGThis diploma thesis deals with the synthesis of conjugates of cyclodextrin with the anticancer drug 5-fluorouracil and folic acid, which works as a targeting group. 5-Fluorouracil is connected to cyclodextrin via an acid-labile linker, which is expected to be cleaved in decreased pH in the proximity of malignant tissue or in the endosome. Malignant tissue also overexpresses receptor for folic acid, and this phenomenon is used for targeted delivery of therapeutic agents. Cyclodextrins are cyclic oligosaccharides, which are known for their ability to complex various compounds into their hydrophobic cavity and increase solubility, stability and bioavailability of these compounds. A synthetic approach for the preparation of conjugate of cyclode...
<div><p>Drug targeting is an active area of research and nano-scaled drug delivery systems hold trem...
The tumour targeting properties of a new drug carrier synthesised by bioconjugation of folic acid to...
A large number of antitumor drug delivery carriers based on passive targeting and/or active targetin...
A synthesis procedure was set up aimed at preparing a new tumor targetable drug carrier based on \uf...
A new cyclodextrin-based carrier for active targeting of low soluble and degradable drugs has been s...
Transformations of the difunctionalizated cyclodextrin derivatives is a daunting task due to the cha...
I have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carr...
A general disadvantage of chemotherapy is that the drugs cannot discriminate between fast-growing ca...
During this doctoral research work new potential drug delivery vehicles for targeted treatment of ca...
Folic acid has emerged as an interesting cell-targeting moiety and a number of drugs have been conju...
Since 1970s cyclodextrins (CDs) and their derivatives, in virtue of their peculiar inclusion propert...
Cyclodextrins are natural macrocyclic oligosaccharides able to form inclusion complexes with a wide ...
Onkološke bolesti su drugi uzrok smrtnosti u svijetu, a broj oboljelih raste. Terapija tumora uništa...
Drug targeting is an active area of research and nano-scaled drug delivery systems hold tremendous p...
The tumor targeting properties of a new drug carrier synthesized by bioconjugation of folic acid (FA...
<div><p>Drug targeting is an active area of research and nano-scaled drug delivery systems hold trem...
The tumour targeting properties of a new drug carrier synthesised by bioconjugation of folic acid to...
A large number of antitumor drug delivery carriers based on passive targeting and/or active targetin...
A synthesis procedure was set up aimed at preparing a new tumor targetable drug carrier based on \uf...
A new cyclodextrin-based carrier for active targeting of low soluble and degradable drugs has been s...
Transformations of the difunctionalizated cyclodextrin derivatives is a daunting task due to the cha...
I have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carr...
A general disadvantage of chemotherapy is that the drugs cannot discriminate between fast-growing ca...
During this doctoral research work new potential drug delivery vehicles for targeted treatment of ca...
Folic acid has emerged as an interesting cell-targeting moiety and a number of drugs have been conju...
Since 1970s cyclodextrins (CDs) and their derivatives, in virtue of their peculiar inclusion propert...
Cyclodextrins are natural macrocyclic oligosaccharides able to form inclusion complexes with a wide ...
Onkološke bolesti su drugi uzrok smrtnosti u svijetu, a broj oboljelih raste. Terapija tumora uništa...
Drug targeting is an active area of research and nano-scaled drug delivery systems hold tremendous p...
The tumor targeting properties of a new drug carrier synthesized by bioconjugation of folic acid (FA...
<div><p>Drug targeting is an active area of research and nano-scaled drug delivery systems hold trem...
The tumour targeting properties of a new drug carrier synthesised by bioconjugation of folic acid to...
A large number of antitumor drug delivery carriers based on passive targeting and/or active targetin...