Uncommon tumors of urogenital tract, their biological behaviour, morphology and cytogenetics

Current doctoral thesis is dealing with biological behavior, morphology and cytogenetical features of rare urogenital tumors with a particular emphasis on renal tumors. Dr. Kvetoslava Michalova (birth name Peckova) was focused on this topic during her postgradual study at Charles University in Prague, Medical Faculty in Pilsen, in years 2014-2017. In her publication activity, the author focused on rare tumors of urogenital tract. The 20 publications published over a span of three years are presented in a form of a commentary. Seven of them are first-author papers and these are briefly introduced below. The first paper entitled "Renal cell carcinoma with leiomyomatous stroma- further immunohistochemical and molecular genetic characteristics of unusual entity" dealt with the relationship between renal cell carcinoma (RCC) with leiomyomatous stroma (LS) and clear cell RCC with reactive LS. It led to the conclusion, that only genetic analysis of VHL gene mutation, VHL hypermatylation and chromosome 3p loss of heterozygosity can be used as a distinguishing tool. The "real" RCC with LS lack the above described genetic abnormalities which is in contrary to the clear cell RCC, which is characterized by them. The distinction between these two entities is of clinical importance, as the "real" RCC with LS..