Current posibilities of laboratory diagnostics of septic state

Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Author: Bc. Karolína Šímová Supervisor: Mgr. Ilona Fátorová Title of diploma thesis: Current posibilities of laboratory diagnostics of septic state The aim of the thesis is to conduct a literature search on the causes of septic conditions, their laboratory and clinical diagnosis and treatment. Furthermore, the aim is to compare laboratory markers for the early detection of sepsis and statistically evaluate the results. The theoretical part deals with the history and development of the definition of sepsis, pathophysiology of septic conditions, their causative agents, risk factors and therapy. Furthermore, it comprises clinical and laboratory diagnostics with emphasis on the description of currently used and potential biomarkers for the diagnosis of sepsis. The practical part consists of statistical analysis of the dependence of selected hematological parameters Ret-He, ICIS score, NLR ratio and biochemical parameters PCT, CRP and IL-6 on the incidence of sepsis or SIRS in the studied group of patients. For all selected parameters, a statistically significant difference was found between the values of the parameter in patients with sepsis or SIRS and those without sepsis or SIRS. Statistically..