Autologous hematopoietic stem cell transplantation in the treatment of systemic sclerosis. Part 2. Safety and complications

O. B. Ovsyannikova
L. P. Ananyeva
O. A. Koneva
L. A. Garzanova
O. V. Desinova
R. U. Shayakhmetova
M. N. Starovoitova
A. M. Lila

Open PDF

Open link

Publication date

February 2021

DOI

10.14412/1996-7012-2021-1-66-72

Publisher

IMA Press, LLC

Journal

Modern Rheumatology Journal

Abstract

Autologous hematopoietic stem cell transplantation (auto-HSCT) is presently the only disease-modifying strategy for the treatment of systemic sclerosis (SSs) that has Level A evidence, the effectiveness of which has been proven in three controlled clinical trials: ASSIST, ASTIS, and SCOT. Despite the positive results obtained with the use of this treatment option, the issues related to its tolerability and safety remain unresolved. The complications caused by obvious immunosuppression and higher frequency of infections are the main causes of death after autoHSCT for autoimmune diseases and occur mainly in the first month after treatment. Overall, the studies performed confirm the overall assessment of auto-HSCT as an effective and relativel...