BackgroundDoxorubicin is one of the most effective chemotherapeutic drugs for breast cancer while its common drug resistance leads to poor patient prognosis and survival. Growing evidence indicate dynamically reorganized chromatin allows rapid access of the gene regulatory machinery to open genomic regions facilitating subsequent gene expression through direct transcription factor (TF) activation and regulatory element binding.MethodsTo better understand the regulatory network underlying doxorubicin resistance in breast cancer cells, we explored the systematic alterations of chromatin accessibility and gene expression by the assay for transposase-accessible chromatin using sequencing (ATAC-seq) in combination with RNA sequencing, followed b...
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor pati...
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistanc...
Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast canc...
Chromatin accessibility plays an important role in defining cell identity and phenotype. With the em...
AbstractMany molecular mechanisms contribute to the development of doxorubicin resistance and differ...
A major goal in the field of transcriptional regulation is the mapping of changes in the binding of ...
Epithelial-to-mesenchymal transition (EMT) is physiological in embryogenesis and wound healing but a...
Breast cancer is a heterogenous disease with some subtypes posing a significant treatment challenge ...
A major goal in the field of transcriptional regulation is the mapping of changes in the binding of ...
African American (AA) women have an excessive risk of developing triple-negative breast cancer (TNBC...
<p>Understanding the mechanisms whereby the sequence of the human genome is interpreted into diverse...
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistanc...
We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer ...
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor pati...
<p>(<b>A</b>) MCF7 cells before and after DOX selection were stained with DAPI to visualize DNA (blu...
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor pati...
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistanc...
Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast canc...
Chromatin accessibility plays an important role in defining cell identity and phenotype. With the em...
AbstractMany molecular mechanisms contribute to the development of doxorubicin resistance and differ...
A major goal in the field of transcriptional regulation is the mapping of changes in the binding of ...
Epithelial-to-mesenchymal transition (EMT) is physiological in embryogenesis and wound healing but a...
Breast cancer is a heterogenous disease with some subtypes posing a significant treatment challenge ...
A major goal in the field of transcriptional regulation is the mapping of changes in the binding of ...
African American (AA) women have an excessive risk of developing triple-negative breast cancer (TNBC...
<p>Understanding the mechanisms whereby the sequence of the human genome is interpreted into diverse...
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistanc...
We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer ...
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor pati...
<p>(<b>A</b>) MCF7 cells before and after DOX selection were stained with DAPI to visualize DNA (blu...
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor pati...
Breast cancer is the leading cause of death in female cancers, and what’s worse, tamoxifen resistanc...
Many chemotherapy regiments are successfully used to treat breast cancer; however, often breast canc...