Effects of Valproic acid drug on Hepatic tissues in female mice

Valproic acid is one of many prescribed drugs that used to control seizures in people with epilepsy and may cause degrees of hepatic toxicity. This study intended to research the histological changes that may happen in liver in relationship with delayed organization and overdose treatment of valproic acid. 35 female albino mice were used, they were divided into four groups, group (I) included 5 animals and served as control group, group (II) included 10 animals and received gradually doses of valproic acid for ten weeks , starting with (15mg/kg/day) as minimum recommended dose and ending with (60mg/kg/day) as maximum recommended dose, group (III) included 10 animals and received overdose (120mg/kg/day) for one week, group (IV) included 10 animals and treated exactly as group (II) then the animals were left for recovery for three weeks. The animals were sacrificed at the end of each period and the liver was extracted. The valproic acid incited numerous histological changes in liver included inflammatory cells, necrosis, hydropic degenerations, angiectasis, accumulation of kupffer cells and pigments, cytological changes and fibers deposition. It can be concluded that valproic acid causes variable degrees of hepatic injuries and the impact was time related. Incomplete recovery was recorded after stopping the drug administration