Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
- Lindsey Mayes-Hopfinger
- Aura Enache
- Jian Xie
- Chou-Long Huang
- Robert Köchl
- Victor L. J. Tybulewicz
- Teresa Fernandes-Alnemri
- Emad S. Alnemri
Publication date
July 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The serine/threonine kinase WNK1 is an inhibitor of chloride efflux. Here the authors show that this inhibition is a means of negatively regulating the activation of the NLRP3 inflammasome in macrophages, leading to reduced inflammatory responses
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