Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans
- Wen-Jun Li
- Chen-Wei Wang
- Li Tao
- Yong-Hong Yan
- Mei-Jun Zhang
- Ze-Xian Liu
- Yu-Xin Li
- Han-Qing Zhao
- Xue-Mei Li
- Xian-Dong He
- Yu Xue
- Meng-Qiu Dong
Publication date
July 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity
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