Caspase-6 participates in a series of neurodegenerative pathways, and has aroused widespread attentions as a promising molecular target for the treatment of neurodegeneration. Caspase-6 is a homodimer with 6 central-stranded β-sheets and 5 α-helices in each monomer. Previous crystallographic studies suggested that the 60′s, 90′s and 130′s helices of caspase-6 undergo a distinctive conformational transition upon substrate binding. Although the caspase-6 structures in apo and active states have been determined, the conformational transition process between the two states remains poorly understood. In this work, perturbation-response scanning (PRS) combined with targeted molecular dynamics (TMD) simulations was employed to unravel the atomisti...
Caspase-6 is activated early in Alzheimer disease (AD) and localize to the pathologic...
Caspase-6 (CASP6) has emerged as an important player in Huntington disease (HD), Alzheimer disease (...
Programmed cell death, or apoptosis is a critical homeostatic pathway that monitors the balance of c...
Caspase-6 is an apoptotic cysteine protease that also governs disease progression in Huntington\u27s...
Caspase-6 is an apoptotic cysteine protease that also governs disease progression in Huntington\u27s...
Caspases are cysteine aspartate proteases that direct programmed cell death in multicellular organis...
The apoptotic effector caspase-6 (CASP6) has been clearly identified as a drug target due to its str...
SummaryCaspases, a family of apoptotic proteases, are increasingly recognized as being extensively p...
Caspase 6 (CASP6) is a neuron degeneration-related protease and is widely considered to be a potenti...
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but...
SummaryAlthough significant efforts have been made to understand the mechanisms of caspase activatio...
<div><p>Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative disea...
Caspases are members of a highly regulated aspartate-cysteine protease family which have important r...
Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase...
Dimeric effectors caspase 3 and caspase 7 are activated by initiator caspase processing. In this stu...
Caspase-6 is activated early in Alzheimer disease (AD) and localize to the pathologic...
Caspase-6 (CASP6) has emerged as an important player in Huntington disease (HD), Alzheimer disease (...
Programmed cell death, or apoptosis is a critical homeostatic pathway that monitors the balance of c...
Caspase-6 is an apoptotic cysteine protease that also governs disease progression in Huntington\u27s...
Caspase-6 is an apoptotic cysteine protease that also governs disease progression in Huntington\u27s...
Caspases are cysteine aspartate proteases that direct programmed cell death in multicellular organis...
The apoptotic effector caspase-6 (CASP6) has been clearly identified as a drug target due to its str...
SummaryCaspases, a family of apoptotic proteases, are increasingly recognized as being extensively p...
Caspase 6 (CASP6) is a neuron degeneration-related protease and is widely considered to be a potenti...
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but...
SummaryAlthough significant efforts have been made to understand the mechanisms of caspase activatio...
<div><p>Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative disea...
Caspases are members of a highly regulated aspartate-cysteine protease family which have important r...
Caspases, a family of cysteine proteases, are major mediators of apoptosis and inflammation. Caspase...
Dimeric effectors caspase 3 and caspase 7 are activated by initiator caspase processing. In this stu...
Caspase-6 is activated early in Alzheimer disease (AD) and localize to the pathologic...
Caspase-6 (CASP6) has emerged as an important player in Huntington disease (HD), Alzheimer disease (...
Programmed cell death, or apoptosis is a critical homeostatic pathway that monitors the balance of c...