Background Cardiac fibrosis is the excessive deposition of extracellular matrix in the heart, triggered by a cardiac insult, aging, genetics, or environmental factors. Molecular imaging of the cardiac extracellular matrix with targeted probes could improve diagnosis and treatment of heart disease. However, although this technology has been used to demonstrate focal scarring arising from myocardial infarction, its capacity to demonstrate extracellular matrix expansion and diffuse cardiac fibrosis has not been assessed. Methods and Results Here, we report the use of collagen-targeted peptides labeled with near-infrared fluorophores for the detection of diffuse cardiac fibrosis in the β2-AR (β-2-adrenergic receptor) overexpressing mouse model ...
There is an unmet medical need for non-invasive, sensitive, and quantitative methods for the assessm...
A heart attack results from the loss of blood flow to an area of cardiac tissue. Termed an infarctio...
Pathological deposition of collagen is a hallmark of kidney fibrosis. To illustrate this process we ...
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis, the de...
Cardiac cells are embedded in a collagen network that provides strength in the heart against tension...
Introduction Pathological formation of fibrosis, is an important feature in many diseases. Fibrosis ...
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiovascular dis...
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis, the de...
Cardiovascular fibrosis resulted from pressure overload or ischemia could alter myocardial stiffness...
The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis) is a...
Background: Fibrosis, which is characterized by the pathological accumulation of collagen, is recogn...
Given the importance of fibrous tissue in leading to myocardial dysfunction and failure in hypertens...
Fibrous tissue accumulation is an integral feature of the adverse structural remodeling of cardiac t...
Myocardial fibrosis is recognized as the pathologic entity of extracellular matrix remodeling. Diffu...
Cardiovascular fibrosis resulted from pressure overload or ischemia could alter myocardial stiffness...
There is an unmet medical need for non-invasive, sensitive, and quantitative methods for the assessm...
A heart attack results from the loss of blood flow to an area of cardiac tissue. Termed an infarctio...
Pathological deposition of collagen is a hallmark of kidney fibrosis. To illustrate this process we ...
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis, the de...
Cardiac cells are embedded in a collagen network that provides strength in the heart against tension...
Introduction Pathological formation of fibrosis, is an important feature in many diseases. Fibrosis ...
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiovascular dis...
Cardiac fibrosis is a major hallmark of cardiac diseases. For evaluation of cardiac fibrosis, the de...
Cardiovascular fibrosis resulted from pressure overload or ischemia could alter myocardial stiffness...
The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis) is a...
Background: Fibrosis, which is characterized by the pathological accumulation of collagen, is recogn...
Given the importance of fibrous tissue in leading to myocardial dysfunction and failure in hypertens...
Fibrous tissue accumulation is an integral feature of the adverse structural remodeling of cardiac t...
Myocardial fibrosis is recognized as the pathologic entity of extracellular matrix remodeling. Diffu...
Cardiovascular fibrosis resulted from pressure overload or ischemia could alter myocardial stiffness...
There is an unmet medical need for non-invasive, sensitive, and quantitative methods for the assessm...
A heart attack results from the loss of blood flow to an area of cardiac tissue. Termed an infarctio...
Pathological deposition of collagen is a hallmark of kidney fibrosis. To illustrate this process we ...