Synthesis of phosphino-triazole ligands

The triazole formation via click chemistry has remained a hot topic in recent years. This thesis disclosed the synthesis of triazole containing phosphine ligand for catalysts work. Chapter 1 gives a brief introduction of click chemistry and usage of triazole in various area. Chapter 2 outlines a synthetic strategy to generate triazole-containing phosphine ligands. These triazole ligands are derived from diaryl or dialkyl phosphine and show good catalytic activity in Suzuki-Miyaura cross-coupling. The relationship between bulkiness and catalytic activity of ligand unveiled by SambVca webtool. Applications of these ligands into lead-like compound preparation has been conducted with satisfactory result. In Chapter 3, phosphine ligands with different number of triazole units are prepared, and the catalytic activity of corresponding ligand-metal complex screened in Suzuki-Miyaura cross-coupling. In addition, corresponding gold complexes of phosphine ligands also been obtained for activity test. Thirteen single-crystal structures were obtained for the bulkiness study of ligand. Chapter 4 has provided three different strategies towards the synthesis of asymmetric version of triazole ligand. And resulting corresponding gold phosphines have been prepared as well for further activity screening