The Association Between Matrix Metalloproteinases-9-1562 C/T Polymorphism and Lung Cancer Susceptibility: A Systematic Review and Meta-Analysis

Introduction: Matrix metalloproteinases (MMPs) are a family of zinc dependent proteinase. Several studies have reported the association between the single nucleotide polymorphisms(C/T) -1562 in the MMP-9 promoter and the risk of cancer. In this study we decided to carry out a comprehensive meta-analysis to obtain a reasonable result about the association between this polymorphism and the risk of lung cancer. Materials and Methods: A complete literature review was conducted within the databases of ISI Web of Knowledge, google scholar and PubMed for studies on lung cancer published from 2002 to 2018. A meta-analysis was conducted which included more than 3000 case and control subjects. The pooled odds ratio (OR) and 95% confidence intervals (CI) were used for dominant, recessive and co-dominant MMP-9 genotypes to assess the strength of the association. Results: Analysis indicated no significant association between MMP-9-1562C/T polymorphism and the risk of lung cancer, dominant model; [CT+TT/CC]: OR=0.972, 95% CI=0.811–1.164, recessive model [CC+CT/TT] OR= 1.027, 95% CI=0.651–1.618 and co-dominant model [TT/ CC] OR=0.983, 95% CI=0.550–1.755. Conclusions: No association was observed between the MMP9-1562 C/T polymorphism and the incidence of lung cancer. Meta-analysis demonstrated that this polymorphism can’t serve as a diagnostic marker for lung cancer