The effect of early probiotic exposure on the preterm infant gut microbiome development
- Yan Hui
- Birgitte Smith
- Martin Steen Mortensen
- Lukasz Krych
- Søren J. Sørensen
- Gorm Greisen
- Karen Angeliki Krogfelt
- Dennis Sandris Nielsen
DOIAbstract
Premature birth, especially if born before week 32 of gestation, is associated with increased risk of neonatal morbidity and mortality. Prophylactic use of probiotics has been suggested to protect preterm infants via supporting a healthy gut microbiota (GM) development, but the suggested strains and doses vary between studies. In this study, we profiled the GM of 5, 10 and 30-day fecal samples from two cohorts of preterm neonates (born <30 weeks of gestation) recruited in the same neonatal intensive care unit. One cohort (n = 165) was recruited from September 2006 to January 2009 before probiotics were introduced in the clinic. The second cohort (n = 87) was recruited from May 2010 to October 2011 after introducing Lacticaseibacillus rhamno...
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