Pathogenetic markers of diagnostics and prediction of chronic kidney disease in children

The authors present their own results of scientific research on the clinical and paraclinical characteristics of various stages of chronic kidney disease in children. They determine pathogenetic markers for the diagnosis and prognosis of chronic kidney disease in childhood with the assessment of the set of endothelial dysfunction markers. The authors proved diagnostic and prognostic value of a stepwise increase in arterial hypertension, urinary excretion of prosclerotic, pro-inflammatory cytokines and growth factors with a simultaneous decrease in urinary excretion of anti-inflammatory cytokines, an increase in the level of microalbuminuria, disturbances of urodynamics and intrarenal hemodynamics.The authors developed an algorithm for the diagnosis of chronic kidney disease in childhood, taking into account pathogenetic factors with an assessment of the complex of clinical and paraclinical, structural, functional parameters, hemodynamic changes in the kidneys in combination with the parameters of endothelial function and cytokine status