Microwave-Enhanced Reaction of Thioacids with Azides in Aqueous Medium

An efficient entry to aromatic amides using microwave irradiation in aqueous medium is described. Starting from substituted anilines, in situ formation of the corresponding aromatic azide is followed by their immediate reaction with a thioacid to yield amides in excellent yield. This improved protocol significantly reduces the reaction time thus increasing the overall efficiency of this useful transformation. © Georg Thieme Verlag Stuttgart - New York