Is health status impaired in childhood cancer survivors? A systematic review and meta-analysis

Background An increase in survival rates of childhood cancer is associated with long-term health issues in survivors. Methods We conducted a systematic review and meta-analysis comparing health status-related endpoints in childhood cancer survivors (CCS) versus controls. Results Eighty-six studies (n = 98,480 participants, 62% CCS) were included in the review. Of these, 73 studies (n = 96,550, 63% CCS) could be meta-analyzed. CCS showed a lower left ventricular ejection and fractional shortening (SMD=-0.59 and -0.55, respectively, both p < 0.01 [n=1,824 and 1,880]), a lower HDL-cholesterol concentration (SMD=-0.48, p<0.001, n=1,378) and a higher waist-to-hip ratio (SMD=0.61, p < 0.01, n=229) than their healthy peers. No significant differences were found for the remaining endpoints. Conclusions CCS is associated with a lower left ventricular function and HDL-cholesterol level, and a higher waist-to-hip ratio than healthy controls. These findings support the need to closely monitor the cardiometabolic health status of CCS and to implement preventive lifestyle interventions for this population.Sin financiación5.833 JCR (2019) Q1, 11/76 Hematology, 44/244 Oncology2.213 SJR (2019) Q1, 4/109 Geriatrics and Gerontology, 10/132 Hematology, 42/367 OncologyNo data IDR 2019UE