Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial
- Fiuza Luces, María del Carmen
- Padilla del Hierro, Julio Rubén
- Valentín, Jaime
- Santana Sosa, Elena
- Santos-Lozano, Alejandro
- Sanchís-Gomar, Fabián
- Pareja Galeano, Helios
- Morales Rojas, Javier Salvador
- Fleck, Steven J.
- Pérez Ruiz, Margarita
- Lassaletta, Álvaro
- Soares-Miranda, Luisa
- Pérez-Martínez, Antonio
- Lucía Mulas, Alejandro
DOIAbstract
The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interventions are safe in pediatric cancer patients with solid tumors during chemotherapy treatment despite its aggressive, immunosuppressive na...
Add to ORKG