Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates
- Dimitra Metallinou
- Grigorios Karampas
- Georgia Nyktari
- Nicoletta Iacovidou
- Katerina Lykeridou
- Demetrios Rizos
DOIAbstract
Neonatal brain injury is a serious adverse outcome of prematurity. Early detection of high risk premature neonates to develop neonatal brain injury is not currently feasible. The predictive value of many biomarkers has been tested, but none is used currently in clinical practice. The purpose of this study was to determine the levels and predictive value of serum glial fibrillary acidic protein (GFAP) in a prospective longitudinal case-control study during the first three days of life in premature neonates (<34 weeks of gestation) that later developed either intraventricular hemorrhage or periventricular leukomalacia. Each case (n=29) was matched according to birth weight and gestational age to one neonate with normal head ultrasound scans. ...
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