Although persistent pain is estimated to affect about 20% of the adult population, current treatments have poor results. Polypharmacology, which is the administration of more than one drug targeting on two or more different sites of action, represents a prominent therapeutic approach for the clinical management of persistent pain. Thus, in the drug discovery process the “one-molecule-multiple targets” strategy nowadays is highly recognized. Indeed, multitarget ligands displaying a better antinociceptive activity with fewer side effects, combined with favorable pharmacokinetic and pharmacodynamic characteristics, have already been shown. Multitarget ligands possessing non-opioid/opioid and opioid/opioid mechanisms of action are considered as...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyper...
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abu...
Opioid receptors are currently classified as mu (mu: mOP), delta (delta: dOP), kappa (kappa: kOP) wi...
Opioid receptors are currently classified as mu (mu: mOP), delta (delta: dOP), kappa (kappa: kOP) wi...
Opioids are among the most effective analgesics available and are the first choice in the treatment ...
The pivotal role of the stereocenter at the N-substituent of the 6,7-benzomorphan scaffold was inves...
Chronic neuropathic pain is a disease that impacts the livelihood of millions of people in the Unite...
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain man...
International audienceOpioid agonists are well-established analgesics, widely prescribed for acute b...
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more ...
The need for safer pain-management therapies with decreased abuse liability inspired a novel drug de...
Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effe...
The opioid pharmacological profile of cis-(−)-N-normetazocine derivatives is deeply affected by the ...
The observation in 1979 that opioid receptors interact, led to the design of bivalent ligands in an ...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyper...
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abu...
Opioid receptors are currently classified as mu (mu: mOP), delta (delta: dOP), kappa (kappa: kOP) wi...
Opioid receptors are currently classified as mu (mu: mOP), delta (delta: dOP), kappa (kappa: kOP) wi...
Opioids are among the most effective analgesics available and are the first choice in the treatment ...
The pivotal role of the stereocenter at the N-substituent of the 6,7-benzomorphan scaffold was inves...
Chronic neuropathic pain is a disease that impacts the livelihood of millions of people in the Unite...
There is still an unmet clinical need to develop new pharmaceuticals for effective and safe pain man...
International audienceOpioid agonists are well-established analgesics, widely prescribed for acute b...
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more ...
The need for safer pain-management therapies with decreased abuse liability inspired a novel drug de...
Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effe...
The opioid pharmacological profile of cis-(−)-N-normetazocine derivatives is deeply affected by the ...
The observation in 1979 that opioid receptors interact, led to the design of bivalent ligands in an ...
Numerous studies have demonstrated a physiological interaction between the mu opioid receptor (MOR) ...
Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyper...
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abu...