Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors are characterized by uncontrolled cell growth and tissue invasiveness and some of them are possibly mediated by gene expression involving G-quadruplexes. The stabilization of G-quadruplex sequences with small molecules is considered a promising strategy in anticancer targeted therapy. Methods: Molecular virtual screening allowed us identifying novel symmetric bifunctionalized naphtho[1,2-b:8,7-b’]dithiophene ligands as interesting candidates targeting h-Telo and c-MYC G-quadruplexes....
The synthesis, biological and molecular modeling evaluation of a series of macrocyclic naphthalene d...
A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadrup...
Targeting of DNA secondary structures, such as G-quadruplexes, is now considered an appealing opport...
Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of s...
G-quadruplexes are specific nucleotide structures of stacked planes of guanines, and can form in G-r...
The DNA at the telomeres and promoter regions of eukaryotic genes is G-rich and may form special DNA...
It is well recognized that the non-canonical DNA structures known as G-quadruplexes (G4s) have a pot...
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. F...
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. F...
Background G-quadruplexes have become important drug-design targets for the treatment of various hum...
G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promot...
Background: G-quadruplexes have become important drug-design targets for the treatment of various hu...
International audienceG-quadruplex (G4) structures are non-canonical DNA/RNA secondary structures ab...
Targeting G-quadruplex structures is currently viewed as a promising anticancer strategy. Searching ...
The synthesis, biological and molecular modeling evaluation of a series of macrocyclic naphthalene d...
A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadrup...
Targeting of DNA secondary structures, such as G-quadruplexes, is now considered an appealing opport...
Background: G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of s...
G-quadruplexes are specific nucleotide structures of stacked planes of guanines, and can form in G-r...
The DNA at the telomeres and promoter regions of eukaryotic genes is G-rich and may form special DNA...
It is well recognized that the non-canonical DNA structures known as G-quadruplexes (G4s) have a pot...
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. F...
G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. F...
Background G-quadruplexes have become important drug-design targets for the treatment of various hum...
G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promot...
Background: G-quadruplexes have become important drug-design targets for the treatment of various hu...
International audienceG-quadruplex (G4) structures are non-canonical DNA/RNA secondary structures ab...
Targeting G-quadruplex structures is currently viewed as a promising anticancer strategy. Searching ...
The synthesis, biological and molecular modeling evaluation of a series of macrocyclic naphthalene d...
A series of trisubstituted naphthalimides have been synthesized and evaluated as telomeric G-quadrup...
Targeting of DNA secondary structures, such as G-quadruplexes, is now considered an appealing opport...