There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surgery. New contrast agents are obtained by substituting the radioactive tag with, or adding a fluorescent cyanine to the molecular structure of antibodies or peptides. This enables intra-operative fluorescent detection of cancerous tissue, leading to more complete tumor resection. However, these fluorescent cyanines can have a remarkable influence on pharmacokinetics and tumor uptake, especially when labeled to smaller targeting vectors such as peptides. Here we demonstrate the effect of cyanine-mediated dead cell-binding of Ac-Lys <sup>0</sup> (IRDye800CW)-Tyr <sup>3</sup> -octreotate (800CW-TATE) and how this can be use...
Necrosis only occurs in pathological situations and is directly related to disease severity and, the...
Hypericin, a naturally occurring red fluorescent photosensitizer, has been of interest in severalres...
Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of ...
There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surge...
BACKGROUND: There is a growing body of nuclear contrast agents that are repurposed for fluorescence-...
BACKGROUND: There is a growing body of nuclear contrast agents that are repurposed for fluorescence-...
Quantification of tumor necrosis in cancer patients is of diagnostic value as the amount of necrosi...
Current clinical measurements for tumor treatment efficiency rely often on changes in tumor volume m...
Purpose: Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine d...
Quantification of tumor necrosis in cancer patients is of diagnostic value as the amount of necrosis...
In this thesis we explore the application and consequences of the dead cell binding by IRDye800CW. W...
Molecular entities that localize in tumor tissue are clinically important for targeted delivery of d...
In molecular imaging, a targeting strategy with ligands is widely used because specificity can be si...
Optical imaging is most favorable for dyes that absorb in the near-IR region because tissue is more ...
This dissertation focuses on two fundamental yet unanswered questions in human health and disease co...
Necrosis only occurs in pathological situations and is directly related to disease severity and, the...
Hypericin, a naturally occurring red fluorescent photosensitizer, has been of interest in severalres...
Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of ...
There is a growing body of nuclear contrast agents that are repurposed for fluorescence-guided surge...
BACKGROUND: There is a growing body of nuclear contrast agents that are repurposed for fluorescence-...
BACKGROUND: There is a growing body of nuclear contrast agents that are repurposed for fluorescence-...
Quantification of tumor necrosis in cancer patients is of diagnostic value as the amount of necrosi...
Current clinical measurements for tumor treatment efficiency rely often on changes in tumor volume m...
Purpose: Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine d...
Quantification of tumor necrosis in cancer patients is of diagnostic value as the amount of necrosis...
In this thesis we explore the application and consequences of the dead cell binding by IRDye800CW. W...
Molecular entities that localize in tumor tissue are clinically important for targeted delivery of d...
In molecular imaging, a targeting strategy with ligands is widely used because specificity can be si...
Optical imaging is most favorable for dyes that absorb in the near-IR region because tissue is more ...
This dissertation focuses on two fundamental yet unanswered questions in human health and disease co...
Necrosis only occurs in pathological situations and is directly related to disease severity and, the...
Hypericin, a naturally occurring red fluorescent photosensitizer, has been of interest in severalres...
Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of ...