Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Le facteur D du complément: toxine urémique [Factor D of complement: Uremic toxin?].

Pascual, M.

January 1991

Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly r...

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases

Loeven, M.A.
Rops, L.W.M.M.
Berden, J.H.M.
Daha, M.R.
Rabelink, T.J.
Vlag, J. van der

January 2015

Contains fulltext : 154249.pdf (publisher's version ) (Closed access)Complement fa...

IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation

Langereis, J.D.
Henriet, S.S.
Kuipers, S.
Weemaes, C.M.R.
Burg, Mirjam van der
Jonge, M.I. de
Flier, M. van der

January 2018

Contains fulltext : 190016.pdf (Publisher’s version ) (Open Access

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections.

Sprong, T.
Roos, D.
Weemaes, C.M.R.
Neeleman, C.
Geesing, C.L.
Mollnes, T.E.
Deuren, M. van

January 2006

Contains fulltext : 51083.pdf (publisher's version ) (Closed access)The complement...

Additional file 1 of Complement factor D is linked to platelet activation in human and rodent sepsis

O. Sommerfeld (11282499)
K. Dahlke (11282502)
M. Sossdorf (11282505)
R. A. Claus (11282508)
A. Scherag (7698284)
M. Bauer (7612679)
F. Bloos (11282511)

August 2021

Additional file 1. Complement factor D is linked to platelet activation in human and rodent sepsis

Complete and Partial Deficiencies of Complement Factor D in a Dutch Family

Pieter S. Hiemstra
Ema Langeler
Betty Compier
L Yvonne Keepers
Peter C. J. Leijh

September 2016

A young man suffering from recurrent Neisseria infections was shown to lack detectable serum complem...

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway

Christopher C. T. Sng (7773827)
Sorcha O'Byrne (7773830)
Daniil M. Prigozhin (7773833)
Matthias R. Bauer (509957)
Jennifer C. Harvey (7773836)
Michelle Ruhle (7773839)
Ben G. Challis (7773842)
Sara Lear (37368)
Lee D. Roberts (4845175)
Sarita Workman (7773845)
Tobias Janowitz (506812)
Lukasz Magiera (7773848)
Rainer Doffinger (6086237)
Matthew S. Buckland (7773851)
Duncan J. Jodrell (7773854)
Robert K. Semple (7773857)
Timothy J. Wilson (538888)
Yorgo Modis (116166)
James E. D. Thaventhiran (7773860)

March 2018

[First paragraph] We investigated an alternative complement pathway (AP) deficiency in a patient wit...

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

Sng, Christopher CT
O'Byrne, Sorcha
Prigozhin, Daniil
Bauer, Matthias R
Harvey, Jennifer C
Ruhle, Michelle
Challis, Ben G
Lear, Sara
Roberts, Lee D
Workman, Sarita
Janowitz, Tobias
Magiera, Lukasz
Doffinger, Rainer
Buckland, Matthew S
Jodrell, Duncan
Semple, Robert K
Wilson, Timothy J
Modis, Yorgo
Thaventhiran, James

July 2018

Abstract Background: Complement factor D (FD) is the rate-limiting enzyme of the alternative comple...

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Jonathan Barratt
Jonathan Barratt
Ilene Weitz

September 2021

The complement system is central to first-line defense against invading pathogens. However, excessiv...

Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

Langereis, J.D.
Pasch, Eva S. van der
Jonge, M.I. de

January 2019

Contains fulltext : 206260.pdf (publisher's version ) (Closed access

Complement factor d in age-related macular degeneration

Stanton, C.M.
Yates, J.R.W.
Hollander, A.I. den
Seddon, J.M.
Swaroop, A.
Stambolian, D.
Fauser, S.
Hoyng, C.B.
Yu, Y.
Atsuhiro, K.
Branham, K.
Othman, M.
Chen, W.
Kortvely, E.
Chalmers, K.
Hayward, C.
Moore, A.T.
Dhillon, B.
Ueffing, M.
Wright, A.F.

January 2011

Contains fulltext : 96746.pdf (publisher's version ) (Closed access)Purpose. To ex...

Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome

Nieuwenhuijzen, G.A.P
Meyer, M.P.D.
Hendriks, T.
Goris, R.J.A.

January 1995

Contains fulltext : 22413.PDF (publisher's version ) (Open Access

Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Aradottir, Sigridur Sunna
Kristoffersson, Ann-Charlotte
Roumenina, Lubka,
Bjerre, Anna
Kashioulis, Pavlos
Palsson, Runolfur
Karpman, Diana

June 2021

International audienceComplement factor B (FB) mutant variants are associated with excessive complem...

Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?

Waters, Aoife
Johnson, Sally

February 2012

Haemolytic uraemic syndrome (HUS) accounts for the most common cause of childhood acute renal failur...

Complement factor D is linked to platelet activation in human and rodent sepsis

O. Sommerfeld
K. Dahlke
M. Sossdorf
R. A. Claus
A. Scherag
M. Bauer
F. Bloos

August 2021

Abstract Background The complement factor D (CFD) exerts a regulatory role during infection. However...

Le facteur D du complément: toxine urémique [Factor D of complement: Uremic toxin?].

Pascual, M.

January 1991

Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly r...

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases

Loeven, M.A.
Rops, L.W.M.M.
Berden, J.H.M.
Daha, M.R.
Rabelink, T.J.
Vlag, J. van der

January 2015

Contains fulltext : 154249.pdf (publisher's version ) (Closed access)Complement fa...

IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation

Langereis, J.D.
Henriet, S.S.
Kuipers, S.
Weemaes, C.M.R.
Burg, Mirjam van der
Jonge, M.I. de
Flier, M. van der

January 2018

Contains fulltext : 190016.pdf (Publisher’s version ) (Open Access

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections.

Sprong, T.
Roos, D.
Weemaes, C.M.R.
Neeleman, C.
Geesing, C.L.
Mollnes, T.E.
Deuren, M. van

January 2006

Contains fulltext : 51083.pdf (publisher's version ) (Closed access)The complement...

Additional file 1 of Complement factor D is linked to platelet activation in human and rodent sepsis

O. Sommerfeld (11282499)
K. Dahlke (11282502)
M. Sossdorf (11282505)
R. A. Claus (11282508)
A. Scherag (7698284)
M. Bauer (7612679)
F. Bloos (11282511)

August 2021

Additional file 1. Complement factor D is linked to platelet activation in human and rodent sepsis

Complete and Partial Deficiencies of Complement Factor D in a Dutch Family

Pieter S. Hiemstra
Ema Langeler
Betty Compier
L Yvonne Keepers
Peter C. J. Leijh

September 2016

A young man suffering from recurrent Neisseria infections was shown to lack detectable serum complem...

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway

Christopher C. T. Sng (7773827)
Sorcha O'Byrne (7773830)
Daniil M. Prigozhin (7773833)
Matthias R. Bauer (509957)
Jennifer C. Harvey (7773836)
Michelle Ruhle (7773839)
Ben G. Challis (7773842)
Sara Lear (37368)
Lee D. Roberts (4845175)
Sarita Workman (7773845)
Tobias Janowitz (506812)
Lukasz Magiera (7773848)
Rainer Doffinger (6086237)
Matthew S. Buckland (7773851)
Duncan J. Jodrell (7773854)
Robert K. Semple (7773857)
Timothy J. Wilson (538888)
Yorgo Modis (116166)
James E. D. Thaventhiran (7773860)

March 2018

[First paragraph] We investigated an alternative complement pathway (AP) deficiency in a patient wit...

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway.

Sng, Christopher CT
O'Byrne, Sorcha
Prigozhin, Daniil
Bauer, Matthias R
Harvey, Jennifer C
Ruhle, Michelle
Challis, Ben G
Lear, Sara
Roberts, Lee D
Workman, Sarita
Janowitz, Tobias
Magiera, Lukasz
Doffinger, Rainer
Buckland, Matthew S
Jodrell, Duncan
Semple, Robert K
Wilson, Timothy J
Modis, Yorgo
Thaventhiran, James

July 2018

Abstract Background: Complement factor D (FD) is the rate-limiting enzyme of the alternative comple...

Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway

Jonathan Barratt
Jonathan Barratt
Ilene Weitz

September 2021

The complement system is central to first-line defense against invading pathogens. However, excessiv...

Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing

Langereis, J.D.
Pasch, Eva S. van der
Jonge, M.I. de

January 2019

Contains fulltext : 206260.pdf (publisher's version ) (Closed access

Complement factor d in age-related macular degeneration

Stanton, C.M.
Yates, J.R.W.
Hollander, A.I. den
Seddon, J.M.
Swaroop, A.
Stambolian, D.
Fauser, S.
Hoyng, C.B.
Yu, Y.
Atsuhiro, K.
Branham, K.
Othman, M.
Chen, W.
Kortvely, E.
Chalmers, K.
Hayward, C.
Moore, A.T.
Dhillon, B.
Ueffing, M.
Wright, A.F.

January 2011

Contains fulltext : 96746.pdf (publisher's version ) (Closed access)Purpose. To ex...

Deficiency of complement factor C5 reduces early mortality but does not prevent organ damage in an animal model of multiple organ dysfunction syndrome

Nieuwenhuijzen, G.A.P
Meyer, M.P.D.
Hendriks, T.
Goris, R.J.A.

January 1995

Contains fulltext : 22413.PDF (publisher's version ) (Open Access

Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

Aradottir, Sigridur Sunna
Kristoffersson, Ann-Charlotte
Roumenina, Lubka,
Bjerre, Anna
Kashioulis, Pavlos
Palsson, Runolfur
Karpman, Diana

June 2021

International audienceComplement factor B (FB) mutant variants are associated with excessive complem...

Is complement a culprit in infection-induced forms of haemolytic uraemic syndrome?

Waters, Aoife
Johnson, Sally

February 2012

Haemolytic uraemic syndrome (HUS) accounts for the most common cause of childhood acute renal failur...

Complement factor D is linked to platelet activation in human and rodent sepsis

O. Sommerfeld
K. Dahlke
M. Sossdorf
R. A. Claus
A. Scherag
M. Bauer
F. Bloos

August 2021

Abstract Background The complement factor D (CFD) exerts a regulatory role during infection. However...

Le facteur D du complément: toxine urémique [Factor D of complement: Uremic toxin?].

Pascual, M.

January 1991

Factor D is an essential enzyme of the alternative pathway of complement. Its catabolism is mainly r...

The role of heparan sulfate as determining pathogenic factor in complement factor H-associated diseases

Loeven, M.A.
Rops, L.W.M.M.
Berden, J.H.M.
Daha, M.R.
Rabelink, T.J.
Vlag, J. van der

January 2015

Contains fulltext : 154249.pdf (publisher's version ) (Closed access)Complement fa...

IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation

Langereis, J.D.
Henriet, S.S.
Kuipers, S.
Weemaes, C.M.R.
Burg, Mirjam van der
Jonge, M.I. de
Flier, M. van der

January 2018

Contains fulltext : 190016.pdf (Publisher’s version ) (Open Access

Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Abstract

Extracted data

Complement factor D haplodeficiency is associated with a reduced complement activation speed and diminished bacterial killing

Abstract

Extracted data

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