Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma
- Dighe, S.G.
- Chen, J.
- Yan, L.
- He, Q.
- Gharahkhani, P.
- Onstad, L.
- Levine, D.M.
- Palles, C.
- Ye, W.
- Gammon, M.D.
- Iyer, P.G.
- Anderson, L.A.
- Liu, G.
- Wu, A.H.
- Dai, J.Y.
- Chow, W.H.
- Risch, H.A.
- Lagergren, J.
- Shaheen, N.J.
- Bernstein, L.
- Corley, D.A.
- Prenen, H.
- DeCaestecker, J.
- MacDonald, D.
- Moayyedi, P.
- Barr, H.
- Love, S.B.
- Chegwidden, L.
- Attwood, S.
- Watson, P.
- Harrison, R.
- Ott, K.
- Moebus, S.
- Venerito, M.
- Lang, H.
- Mayershofer, R.
- Knapp, M.
- Veits, L.
- Gerges, C.
- Weismüller, J.
- Gockel, I.
- Vashist, Y.
- Nöthen, M.M.
- Izbicki, J.R.
- Manner, H.
- Neuhaus, H.
- Rösch, T.
- Böhmer, A.C.
- Hölscher, A.H.
- Anders, M.
- Pech, O.
- Schumacher, B.
- Schmidt, C.
- Schmidt, T.
- Noder, T.
- Lorenz, D.
- Vieth, M.
- May, A.
- Hess, T.
- Kreuser, N.
- Becker, J.
- Ell, C.
- Ambrosone, C.B.
- Moysich, K.B.
- MacGregor, S.
- Tomlinson, I.
- Whiteman, D.C.
- Jankowski, J.
- Schumacher, J.
- Vaughan, T.L.
- Madeleine, M.M.
- Hardie, L.J.
- Buas, M.F.
DOIAbstract
Contains fulltext : 235640.pdf (Publisher’s version ) (Closed access)Genome-wide association studies (GWAS) of esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE), have uncovered significant genetic components of risk, but most heritability remains unexplained. Targeted assessment of genetic variation in biologically relevant pathways using novel analytical approaches may identify missed susceptibility signals. Central obesity, a key BE/EAC risk factor, is linked to systemic inflammation, altered hormonal signaling and insulin-like growth factor (IGF) axis dysfunction. Here, we assessed IGF-related genetic variation and risk of BE and EAC. Principal component analysis was employed to evaluate pathwa...
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