Transglutaminase 2 (TG2) is expressed ubiquitously, has multiple physiological functions and has also been associated with inflammatory diseases, neurodegenerative disorders, autoimmunity and cancer. In particular, TG2 is expressed in small intestine mucosa where it is up-regulated in active coeliac disease (CD). The aim of this work was to investigate the induction of TG2 expression by proinflammatory cytokines [interleukin (IL)-1, IL-6, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and IL-15] and the signalling pathways involved, in human epithelial and monocytic cells and in intestinal tissue from controls and untreated CD patients. Here we report that IFN-γ was the most potent inducer of TG2 expression in the small intestinal mucos...
We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host’s inflammator...
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of g...
Transglutaminase 2 (TG2) is a protein crosslinking enzyme with several additional biochemical functi...
Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestin...
Type 2 transglutaminase (TG2) is a ubiquitous enzyme able to modify gliadin peptides introduced into...
Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and ...
Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and ...
Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of C...
학위논문 (박사)-- 서울대학교 대학원 : 의과학과, 2016. 8. 김인규.Transglutaminase 2 (TG2) is an enzyme that catalyzes post...
Objective The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), reg...
Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies ...
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-depend...
AbstractWheat gliadin is the triggering agent in coeliac disease. In this study, we documented that ...
Mucosal molecular pattern of tissue transglutaminase and interferon gamma in celiac disease with and...
AbstractActivation of small intestinal gluten-reactive CD4+ T cells is a critical event in celiac di...
We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host’s inflammator...
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of g...
Transglutaminase 2 (TG2) is a protein crosslinking enzyme with several additional biochemical functi...
Since tissue transglutaminase-2 (TG2) can represent a marker of inflammation for some gastrointestin...
Type 2 transglutaminase (TG2) is a ubiquitous enzyme able to modify gliadin peptides introduced into...
Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and ...
Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and ...
Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of C...
학위논문 (박사)-- 서울대학교 대학원 : 의과학과, 2016. 8. 김인규.Transglutaminase 2 (TG2) is an enzyme that catalyzes post...
Objective The Crohn's disease (CD) susceptibility gene, protein tyrosine phosphatase N2 (PTPN2), reg...
Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies ...
Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-depend...
AbstractWheat gliadin is the triggering agent in coeliac disease. In this study, we documented that ...
Mucosal molecular pattern of tissue transglutaminase and interferon gamma in celiac disease with and...
AbstractActivation of small intestinal gluten-reactive CD4+ T cells is a critical event in celiac di...
We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host’s inflammator...
Celiac disease (CD) is a chronic inflammation of the small intestine triggered by the ingestion of g...
Transglutaminase 2 (TG2) is a protein crosslinking enzyme with several additional biochemical functi...