Add to ORKGSulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).Facultad de Ciencias Exacta
The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neu...
Sulfamate and its derivatives have a range of biological activities. One-pot cyclocondensation of al...
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with ...
Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 200...
We report herein the design and optimization of a novel series of sulfamides and sulfamates derived ...
Functional amino acids (FAAs) and α-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs)...
A theoretical study of the mechanisms associated with the synthesis of anticonvulsant symmetric N,N’...
There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, s...
A set of sulfamides designed, synthesized and evaluated against maximal electroshock seizure (MES) a...
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides ...
Primary Amino Acid Derivatives (PAADs) (N′-benzyl 2-substituted 2-amino acetamides) are structurally...
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared an...
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared an...
The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent...
The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neu...
The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neu...
Sulfamate and its derivatives have a range of biological activities. One-pot cyclocondensation of al...
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with ...
Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 200...
We report herein the design and optimization of a novel series of sulfamides and sulfamates derived ...
Functional amino acids (FAAs) and α-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs)...
A theoretical study of the mechanisms associated with the synthesis of anticonvulsant symmetric N,N’...
There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, s...
A set of sulfamides designed, synthesized and evaluated against maximal electroshock seizure (MES) a...
A novel series of benzenesulfonamide derivatives containing 4-aminobenzenesul-fonamide and α-amides ...
Primary Amino Acid Derivatives (PAADs) (N′-benzyl 2-substituted 2-amino acetamides) are structurally...
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared an...
Six novel 3″-substituted (R)-N-(phenoxybenzyl) 2-N-acetamido-3-methoxypropionamides were prepared an...
The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent...
The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neu...
The functionalized amino acid, lacosamide ((R)-2), and the α-aminoamide, safinamide ((S)-3), are neu...
Sulfamate and its derivatives have a range of biological activities. One-pot cyclocondensation of al...
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with ...