The protective effects of Olive leaf extract on Type 2 diabetes, the expression of liver superoxide dismutase and total antioxidant capacity of plasma in rats

Olive leaf has also medicinal benefits in type 2 diabetes. The aim of this cross-sectional study was to evaluate the effects of olive leaf extract on prevention of type 2 diabetes induced by Streptozotocin and nicotinamide, assessment of the expression of liver superoxide dismutase enzyme gene and total antioxidant capacity of plasma in rats. In this study 28 healthy, mature, Sprague-Dawely male rats with the initial weight of 250 ± 50 g were divided into 4 equal groups (group1: Healthy control; group2: Healthy Trial; group3: Diabetic control; group4: Diabetic Trial). Fasting blood glucose in all rats was measured every week with glucose oxidase method. At the end of our study, after sacrificing mice, all experiments were measured. Fasting blood glucose was not significant difference in the group 4(439 ± 47mg/dl) and group 3 (445 ± 33 mg/dl) but with group1(85 ± 11 mg/dl) significant difference was observed. There was no significant difference between total antioxidant activity and nitric oxide metabolites in groups but expression of superoxide dismutase gene was significantly increased in group2 and group3 (p