IQGAP3 May Serve as a Promising Biomarker in Clear Cell Renal Cell Carcinoma

Quan Meng,1,* Can-Xuan Li,2,* Dan Long,3 Xiaobin Lin4 1Department of Clinical Laboratory, Shenzhen Traditional Chinese Medical Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Department of urology, Shenshan Central Hospital, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Shanwei, Guangdong, People’s Republic of China; 3Respiratory Medicine, Shenshan Central Hospital, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Shanwei, Guangdong, People’s Republic of China; 4Department of Breast Surgery and General Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaobin LinDepartment of Breast Surgery and General Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of ChinaEmail lxb826463580@163.comAim: The study was designed to mine the expression and roles of IQGAP3 in clear cell renal cell carcinoma (ccRCC).Methods: Expression profiles and clinical information were obtained from the Cancer Genome Atlas (TCGA) to estimate IQGAP3 expression in ccRCC, its relationship with patients’ clinicopathological variables and prognosis, and the potential biological mechanisms.Results: IQGAP3 was highly expressed in ccRCC and indicated advanced clinical outcome and poor prognosis. IQGAP3 affected the progression of ccRCC through several cancer-related pathways. IQGAP3 might play a vital role in the ccRCC tumor microenvironment.Conclusion: IQGAP3 could serve as a promising prognostic biomarker and therapeutic target.Keywords: IQGAP3, clear cell renal cell carcinoma, prognosi