Summary: T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they have adverse cardiovascular side effects. In homeostasis, the transporter SPNS2 supplies lymph S1P and enables T cell exit, while the transporter MFSD2B supplies most blood S1P and supports vascular function. It is unknown whether SPNS2 remains necessary to supply lymph S1P during an immune response, or whether in inflammation other compensatory transporters are upregulated. Here, using a model of dermal inflammation, we demonstrate that SPNS2 s...
SummaryThe mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promote lymphocyte e...
T cell,migration,sphingosine-1-phosphate,S1P receptorT cell exit from lymphoid organs is mediated by...
SummarySphingosine-1-phosphate (S1P) helps mediate lymphocyte egress from lymph nodes, yet many mech...
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph...
Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide...
SummaryPlasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1...
Effective adaptive immune responses require a large repertoire of naive T cells that migrate through...
Lymphocyte egress from peripheral lymphoid organs during recirculation is essential for normal immun...
Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein– coupled receptor that is critical for prop...
Simmons S., Sasaki N., Umemoto E., et al. High-endothelial cell-derived s1p regulates dendritic cell...
Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in...
BACKGROUND: Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; leve...
Sphingosine-1-phosphate receptor 1 (S1P(1)) was recently shown to be required for lymphocyte egress ...
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the...
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting ti...
SummaryThe mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promote lymphocyte e...
T cell,migration,sphingosine-1-phosphate,S1P receptorT cell exit from lymphoid organs is mediated by...
SummarySphingosine-1-phosphate (S1P) helps mediate lymphocyte egress from lymph nodes, yet many mech...
T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph...
Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide...
SummaryPlasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1...
Effective adaptive immune responses require a large repertoire of naive T cells that migrate through...
Lymphocyte egress from peripheral lymphoid organs during recirculation is essential for normal immun...
Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein– coupled receptor that is critical for prop...
Simmons S., Sasaki N., Umemoto E., et al. High-endothelial cell-derived s1p regulates dendritic cell...
Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in...
BACKGROUND: Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; leve...
Sphingosine-1-phosphate receptor 1 (S1P(1)) was recently shown to be required for lymphocyte egress ...
BACKGROUND: S1PL is an aldehyde-lyase that irreversibly cleaves sphingosine 1-phosphate (S1P) in the...
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting ti...
SummaryThe mechanism by which sphingosine-1-phosphate receptor-1 (S1P1) acts to promote lymphocyte e...
T cell,migration,sphingosine-1-phosphate,S1P receptorT cell exit from lymphoid organs is mediated by...
SummarySphingosine-1-phosphate (S1P) helps mediate lymphocyte egress from lymph nodes, yet many mech...