Summary: The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, including epileptogenesis, is appealing but controversial because of the technical difficulty of probing endogenous GABAergic synaptic function in vivo. We overcome this challenge by non-invasive extracellular recording of neuronal firing responses to optogenetically evoked and spontaneously occurring inhibitory perisomatic GABAergic field potentials, generated by individual parvalbumin interneurons on their target pyramidal cells. Our direct probing of GABAergic transmission suggests a rather anecdotal participation of excitatory GABA in two specific models of epileptogenesis in the mouse CA3 circuit in vivo, even though this does not precl...
It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs) originat...
Neocortical microcircuits are thought to contribute importantly to the sophisticated processing abil...
Objective: Low-level somatic mosaicism in the brain has been shown to be a major genetic cause of in...
The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, includin...
International audienceProbing the polarity of spontaneous perisomatic GABAergic synaptic transmissio...
International audienceDuring brain development, there is a progressive reduction of intracellular ch...
<p><b>A,</b> Perisomatic synapses in PCs of a γ2 KD mouse. α-DG (green) co-localizes precisely with ...
International audienceBackground: Neurological disorders are often characterized by an excessive and...
The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The s...
It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs) originat...
© 2016 the authors.To investigate excitatory and inhibitory GABA actions in cortical neuronal networ...
The mouse motor cortex exhibits spontaneous activity in the form of temporal sequences of neuronal e...
Axonal sprouting of excitatory neurons is frequently observed in temporal lobe epilepsy, but the ext...
International audienceKEY POINTS:Cation-chloride cotransporters (CCCs) play a critical role in contr...
International audienceEpilepsy is characterized by recurrent seizures and brief, synchronous bursts ...
It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs) originat...
Neocortical microcircuits are thought to contribute importantly to the sophisticated processing abil...
Objective: Low-level somatic mosaicism in the brain has been shown to be a major genetic cause of in...
The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, includin...
International audienceProbing the polarity of spontaneous perisomatic GABAergic synaptic transmissio...
International audienceDuring brain development, there is a progressive reduction of intracellular ch...
<p><b>A,</b> Perisomatic synapses in PCs of a γ2 KD mouse. α-DG (green) co-localizes precisely with ...
International audienceBackground: Neurological disorders are often characterized by an excessive and...
The stargazer mutant mouse is an animal model of human absence epilepsy and cerebellar ataxia. The s...
It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs) originat...
© 2016 the authors.To investigate excitatory and inhibitory GABA actions in cortical neuronal networ...
The mouse motor cortex exhibits spontaneous activity in the form of temporal sequences of neuronal e...
Axonal sprouting of excitatory neurons is frequently observed in temporal lobe epilepsy, but the ext...
International audienceKEY POINTS:Cation-chloride cotransporters (CCCs) play a critical role in contr...
International audienceEpilepsy is characterized by recurrent seizures and brief, synchronous bursts ...
It was recently shown that perisomatic GABAergic inhibitory postsynaptic potentials (IPSPs) originat...
Neocortical microcircuits are thought to contribute importantly to the sophisticated processing abil...
Objective: Low-level somatic mosaicism in the brain has been shown to be a major genetic cause of in...