Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, health systems, and on society as a whole. Diabetic retinopathy is one of the most common and serious complications of diabetes, and an established risk factor for blindness in adults. Over 15 years of investigation led to the identification of vascular endothelial growth factor (VEGF) as a main pathogenic factor in diabetic retinopathy and to the introduction of highly effective anti-VEGF-based therapies, such as the monoclonal antibody bevacizumab or its fragment ranibizumab, which helped to prevent diabetes-related blindness in millions of patients. Recently, a pathogenic role for uncontrolled increases in the extracellular ATP concentration (...
Abstract Background Purinergic receptors are expressed in different tissues including the retina. Th...
Objective—We have investigated expression and function of the P2X7 receptor in fibroblasts from heal...
AIM: To discuss the functional significance of purine receptor P2X7 in retinal capillary pericytes r...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Aims: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
The P2X7 receptor (P2X7R) is a membrane receptor for the extracellular adenosine triphosphate (ATP)....
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
The P2X7 receptor is expressed in both anterior and posterior segments of the eyeball. In the ocular...
P2X7 receptors can be found in many tissues and organs, where they mediate several biological functi...
P2X7 receptors can be found in many tissues and organs, where they mediate several biological functi...
Abstract Background Purinergic receptors are expressed in different tissues including the retina. Th...
Objective—We have investigated expression and function of the P2X7 receptor in fibroblasts from heal...
AIM: To discuss the functional significance of purine receptor P2X7 in retinal capillary pericytes r...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Diabetes is a worldwide emergency. Its chronic complications impose a heavy burden on patients, heal...
Aims: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
The P2X7 receptor (P2X7R) is a membrane receptor for the extracellular adenosine triphosphate (ATP)....
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
AIMS: Retinopathy is a leading cause of vision impairment in diabetes. Its pathogenesis involves inf...
The P2X7 receptor is expressed in both anterior and posterior segments of the eyeball. In the ocular...
P2X7 receptors can be found in many tissues and organs, where they mediate several biological functi...
P2X7 receptors can be found in many tissues and organs, where they mediate several biological functi...
Abstract Background Purinergic receptors are expressed in different tissues including the retina. Th...
Objective—We have investigated expression and function of the P2X7 receptor in fibroblasts from heal...
AIM: To discuss the functional significance of purine receptor P2X7 in retinal capillary pericytes r...