Charting the landscape of 5hmC in human tissues is fundamental to understanding its regulatory functions. Here, we systematically profiled the whole-genome 5hmC landscape at single-base resolution for 19 types of human tissues and found 5hmC shows tissue-specific patterns
CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T ...
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation disti...
5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mam...
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5...
5-hydroxymethylcytosine (5-hmC) is a modified form of cytosine recently found in mammalians and is b...
SummaryThe study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to ma...
To improve the epigenomic analysis of tissues rich in 5-hydroxymethylcytosine (hmC), we developed a ...
Abstract Background 5-Hydroxymethylcytosine (5hmC) was recently found to be abundantly present in ce...
Mammalian DNA methylathion is a chemical reaction catalyzed by DNA methyltransferases (DNMTs) and i...
content of human genes Tissue type is a major modifier of the 5-hydroxymethylcytosin
International audienceInvestigating 5-methylcytosine (5mC) has led to many hypotheses regarding mole...
Cytosine residues in the vertebrate genome are enzymatically modified to 5-methylcytosine, which par...
Methylation at the 5-position of cytosine is a well-studied epigenetic pathway. In addition to 5-met...
The epigenetic mark 5-hydroxymethylcytosine (5-hmC) is a distinct product of active DNA demethylatio...
The recent discovery that methylated cytosines are converted to 5-hydroxymethylated cytosines (5hmC)...
CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T ...
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation disti...
5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mam...
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5...
5-hydroxymethylcytosine (5-hmC) is a modified form of cytosine recently found in mammalians and is b...
SummaryThe study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of a method to ma...
To improve the epigenomic analysis of tissues rich in 5-hydroxymethylcytosine (hmC), we developed a ...
Abstract Background 5-Hydroxymethylcytosine (5hmC) was recently found to be abundantly present in ce...
Mammalian DNA methylathion is a chemical reaction catalyzed by DNA methyltransferases (DNMTs) and i...
content of human genes Tissue type is a major modifier of the 5-hydroxymethylcytosin
International audienceInvestigating 5-methylcytosine (5mC) has led to many hypotheses regarding mole...
Cytosine residues in the vertebrate genome are enzymatically modified to 5-methylcytosine, which par...
Methylation at the 5-position of cytosine is a well-studied epigenetic pathway. In addition to 5-met...
The epigenetic mark 5-hydroxymethylcytosine (5-hmC) is a distinct product of active DNA demethylatio...
The recent discovery that methylated cytosines are converted to 5-hydroxymethylated cytosines (5hmC)...
CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T ...
Despite recent evidence that 5-hydroxymethylcytosine (5hmC) possesses roles in gene regulation disti...
5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diverse cell types in mam...