A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
- Christopher Thomas
- Benjamin Wetherall
- Mark D. Levasseur
- Rebecca J. Harris
- Scott T. Kerridge
- Jonathan M. G. Higgins
- Owen R. Davies
- Suzanne Madgwick
Publication date
July 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression
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