Genome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus
- Heuberger-Slot, E. (Evelien)
- R.G. (Ruben) Boers
- J.B. (Joachim) Boers
- W.F.J. (Wilfred) van Ijcken
- D (Dick) Tibboel
- J. (Joost) Gribnau
- R.J. (Robbert) Rottier
- J.E.M.M. (Annelies) de Klein
Publication date
July 2021
DOI Publisher
Springer Science and Business Media LLCAbstract
Background: Alveolar capillary dysplasia with or without misalignment of the pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with a variety of heterozygous genomic alterations in the FOXF1 gene or its 60 kb enhancer. Cases without a genomic alteration in the FOXF1 locus have been described as well. The mechanisms responsible for FOXF1 ha
Add to ORKG