Chronic Obstructive Pulmonary Disease Is Associated with Low Levels of Vitamin D
- Persson, Louise Jeanette Pauline
- Aanerud, Marianne
- Hiemstra, Pieter Sicco
- Hardie, Jon Andrew
- Bakke, Per
- Eagan, Tomas Mikal
DOIAbstract
Introduction: COPD patients may be at increased risk for vitamin D (25(OH)D) deficiency, but risk factors for deficiency among COPD patients have not been extensively reported. Methods: Serum 25(OH)D levels were measured by liquid chromatography double mass spectrometry in subjects aged 40–76 years from Western Norway, including 433 COPD patients (GOLD stage II-IV) and 325 controls. Levels <20 ng/mL defined deficiency. Season, sex, age, body mass index (BMI), smoking, GOLD stage, exacerbation frequency, arterial oxygen tension (PaO2), respiratory symptoms, depression (CES-D score≥16), comorbidities (Charlson score), treatment for osteoporosis, use of inhaled steroids, and total white blood count were examined for associations with 25(OH)D i...
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