Attributes used for cancer screening discrete choice experiments: A systematic review

This is the author accepted manuscript. The final version is available from Springer via the DOI in this record12 November 2021: A Correction to this paper has been published: https://doi.org/10.1007/s40271-021-00562-8Background: Evidence from discrete choice experiments (DCEs) can be used to enrich understanding of preferences, inform the (re)design of screening programs and/or improve communication within public campaigns about the benefits and harms of screening. However, reviews of screening DCEs highlight significant discrepancies between stated choices and real choices, particularly regarding willingness to undergo cancer screening. The identification and selection of attributes and associated levels is a fundamental component of designing a DCE. Misspecification or misinterpretation of attributes may lead to non-compensatory behaviours, attribute non-attendance and responses that lack external validity. Objectives: To synthesise evidence on attribute development, alongside an in-depth review of included attributes and methodological challenges, to provide a resource for researchers undertaking future studies in cancer screening. Methods: A systematic review was conducted to identify DCEs estimating preferences towards cancer screening, dated between 1990 and December 2020. Data were synthesised narratively. In-depth analysis of attributes lead to classification into four categories: test-specific, service delivery, outcomes and monetary. Attribute significance and relative importance were also analysed. The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) conjoint analysis checklist was used to assess the quality of reporting. Results: Forty-nine studies were included at full-text. They covered a range of cancer sites: over half (26/49) examined colorectal screening. Most studies elicited general public preferences (34/49). In total, 280 attributes were included, 90% (252/280) of which were significant. Overall, test sensitivity and mortality reduction were most frequently found to be the most important to respondents. Conclusions: Improvements in reporting the identification, selection and construction of attributes used within cancer screening DCEs are needed. This review also highlights the importance of considering the complexity of choice tasks when considering risk information or compound attributes. Patient and public involvement and stakeholder engagement are recommended to optimise understanding of unavoidably complex choice tasks throughout the design process. To ensure quality and maximise comparability across studies, further research is needed to develop a risk of bias measure for DCEs.Cancer Research U