The use of synthetic inorganic fertilizers containing chemical compounds cause soil quality to decrease. Chromolaena odorata are potential weeds used as a source of organic matter, which can be used as compost. This research aimed to determine the effect of Chromolaena odorata compost on the soil and nutrient uptake of lettuce. The research was conducted using a single factor experimental method arranged in a Randomized Complete Block Design. The treatments tested were the applications of C. odorata weed compost at various doses (222 grams/pot, 444 grams/pot, and 666 grams/pot) with control treatments of 200 ml/pot NPK Phonska (15:15:15), 320 grams/pot cow manure, and without fertilization. The experiment consisted of three blocks with thre...