Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. However, whole body knockout of GPR17 in mice of the C57Bl/6 strain did not affect energy balance, whereas selective knockout in oligodendrocytes or pro-opiomelanocortin neurons provided protection from high fat diet-induced obesity and impaired glucose homeostasis. We reasoned that whole body knockout of GPR17 in mice of the 129 strain might elicit more marked effects because the 129 strain is more susceptible than the C57Bl/6 strain to increased sympathetic activity and less susceptible to high fat diet-induced obesity. Consistent with this hypothesis, compared to wild-type mice, and when fed on either a chow or a high fat diet, GPR17 -/- mice...
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes ...
SummaryDespite high leptin levels, most obese humans and rodents lack responsiveness to its appetite...
SummaryHypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating foo...
Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. How...
BACKGROUND: Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) c...
Obesity susceptibility in humans and in rodent strains varies in response to the consumption of high...
SummaryObesity is characterized by hyperleptinemia and decreased response to exogenous leptin. This ...
Rodents with mutations in the leptin, or leptin receptor, genes have been extensively used to invest...
Summary: The CNS plays a pivotal role in energy homeostasis, but whether oligodendrocytes are involv...
Maintenance of reduced body weight is associated both with reduced energy expenditure per unit metab...
Obesity and associated disorders are becoming one of the most serious problems for healthcare system...
OBJECTIVE: G-protein coupled receptor 75 (GPR75) has been identified as the high-affinity receptor o...
OBJECTIVE: Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defe...
Background: Leptin is an adipocyte-derived hormone that plays a critical role in energy homeostasis ...
Objective: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-i...
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes ...
SummaryDespite high leptin levels, most obese humans and rodents lack responsiveness to its appetite...
SummaryHypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating foo...
Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. How...
BACKGROUND: Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) c...
Obesity susceptibility in humans and in rodent strains varies in response to the consumption of high...
SummaryObesity is characterized by hyperleptinemia and decreased response to exogenous leptin. This ...
Rodents with mutations in the leptin, or leptin receptor, genes have been extensively used to invest...
Summary: The CNS plays a pivotal role in energy homeostasis, but whether oligodendrocytes are involv...
Maintenance of reduced body weight is associated both with reduced energy expenditure per unit metab...
Obesity and associated disorders are becoming one of the most serious problems for healthcare system...
OBJECTIVE: G-protein coupled receptor 75 (GPR75) has been identified as the high-affinity receptor o...
OBJECTIVE: Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defe...
Background: Leptin is an adipocyte-derived hormone that plays a critical role in energy homeostasis ...
Objective: A major challenge for obesity treatment is the maintenance of reduced body weight. Diet-i...
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes ...
SummaryDespite high leptin levels, most obese humans and rodents lack responsiveness to its appetite...
SummaryHypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating foo...