Hox genes are key developmental patterning genes that impact segmental identity and skeletal patterning. Hox11 genes are known to impact wrist and ankle development and are expressed around the developing pisiform and calcaneus. These paralogous bones in the wrist and ankle are the only carpal and tarsal to form a growth plate in mammals, although humans have lost this growth plate and the associated primary ossification center in the pisiform. Loss-of-function mutations to Hoxa11 and Hoxd11 result in pisiform truncation and appear to also cause at least some disorganization of the growth plate cartilage; however, little is known about the nature of this disorganization or if ossification timing is impacted by Hox11 genes. The present study...
Loss-of-function experiments have demonstrated that the establishment of the limb architecture relie...
The mammalian skeleton boasts a remarkable capacity to completely restore the original structure and...
AbstractHox genes show related sequences and overlapping expression domains that often reflect funct...
Hox genes are key developmental patterning genes that impact segmental identity and skeletal pattern...
Hox11 genes are expressed around the developing wrist and ankle and are known to substantially impac...
The human pisiform is a small, nodular, although functionally significant, bone of the wrist. In mos...
Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are ne...
The mesopodium forms at the boundary between the zeugopod and autopod and is composed of short nodul...
Hox genes are indispensable for the proper patterning of the skeletal morphology of the axial and ap...
The HoxdDel(11-13) mutant is one of the animal models for human synpolydactyly, characterized by sho...
AbstractThe HoxdDel(11–13) mutant is one of the animal models for human synpolydactyly, characterize...
The molecular mechanisms that govern bone and joint formation are complex, involving an integrated n...
Limb skeletal elements are connected by distinct synovial joints, but the mechanisms regulating join...
The molecular mechanisms that govern bone and joint formation are complex, involving an integrated n...
During limb development, posterior Hox genes of the Hoxa- and Hoxd cluster provide positional inform...
Loss-of-function experiments have demonstrated that the establishment of the limb architecture relie...
The mammalian skeleton boasts a remarkable capacity to completely restore the original structure and...
AbstractHox genes show related sequences and overlapping expression domains that often reflect funct...
Hox genes are key developmental patterning genes that impact segmental identity and skeletal pattern...
Hox11 genes are expressed around the developing wrist and ankle and are known to substantially impac...
The human pisiform is a small, nodular, although functionally significant, bone of the wrist. In mos...
Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are ne...
The mesopodium forms at the boundary between the zeugopod and autopod and is composed of short nodul...
Hox genes are indispensable for the proper patterning of the skeletal morphology of the axial and ap...
The HoxdDel(11-13) mutant is one of the animal models for human synpolydactyly, characterized by sho...
AbstractThe HoxdDel(11–13) mutant is one of the animal models for human synpolydactyly, characterize...
The molecular mechanisms that govern bone and joint formation are complex, involving an integrated n...
Limb skeletal elements are connected by distinct synovial joints, but the mechanisms regulating join...
The molecular mechanisms that govern bone and joint formation are complex, involving an integrated n...
During limb development, posterior Hox genes of the Hoxa- and Hoxd cluster provide positional inform...
Loss-of-function experiments have demonstrated that the establishment of the limb architecture relie...
The mammalian skeleton boasts a remarkable capacity to completely restore the original structure and...
AbstractHox genes show related sequences and overlapping expression domains that often reflect funct...