Add to ORKGPAPER 1 In the first paper we show that reducing the average molecular weight from ~350 kDa to <6kDa by acid hydrolysis diminished the cell-stimulating activity of poly-M, measured as TNFproduction from human monocytes. However, the activity of the resulting oligomers (M-blocks) was greatly enhanced when covalently attached to particles (plastic beads or biodegradable albumin particles). Similar results were obtained with detoxified/deacylated LPS (DLPS) and glucuronic acid polymers (C6OXY), but not with G-blocks that by themselves are not active. These results suggest that the supramolecular structure affects the potency of polysaccharide stimuli, and that M-blocks attached to biodegradable albumin particles could possibly be exploited as...
The glycoprotein gp43 is an immunodominant antigen secreted by Paracoccidioides brasiliensis, the ag...
Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associa...
Abstract: Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, pl...
<p>(A) Polymers block cell surface receptor expression post CpG but not LPS stimulation. BMDC were c...
In order to examine the possible implication of capsular polysaccharide (CP) types 5 and 8 (CP5 and ...
International audienceThe Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known t...
Mannose receptor (MR) is an endocytic lectin receptor with the capacity to bind sugars and collagen ...
Humans can be exposed to nano-and microplastics (NMP’s) via diet, inhalation, and possibly dermal ro...
The cytokine network is one of the major controlling systems of the inflammatory process, driving th...
We used flow cytometry to determine how LPS-binding protein (LBP) effects the binding of fluorescein...
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases,...
Receptors for the third component of complement (C3) on cultured human monocytes (MO) bind ligand-co...
Previously we demonstrated that two soluble(s) tumor necrosis factor receptors, TNF-R55 as well as s...
Implantation of a biomaterial into the body elicits a host foreign body response, during which polym...
Polyadenylation is a universal step in the maturation of all eukaryotic mRNAs except histone mRNAs. ...
The glycoprotein gp43 is an immunodominant antigen secreted by Paracoccidioides brasiliensis, the ag...
Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associa...
Abstract: Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, pl...
<p>(A) Polymers block cell surface receptor expression post CpG but not LPS stimulation. BMDC were c...
In order to examine the possible implication of capsular polysaccharide (CP) types 5 and 8 (CP5 and ...
International audienceThe Nod-like receptor family protein 3 (NLRP3)-inflammasome pathway is known t...
Mannose receptor (MR) is an endocytic lectin receptor with the capacity to bind sugars and collagen ...
Humans can be exposed to nano-and microplastics (NMP’s) via diet, inhalation, and possibly dermal ro...
The cytokine network is one of the major controlling systems of the inflammatory process, driving th...
We used flow cytometry to determine how LPS-binding protein (LBP) effects the binding of fluorescein...
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases,...
Receptors for the third component of complement (C3) on cultured human monocytes (MO) bind ligand-co...
Previously we demonstrated that two soluble(s) tumor necrosis factor receptors, TNF-R55 as well as s...
Implantation of a biomaterial into the body elicits a host foreign body response, during which polym...
Polyadenylation is a universal step in the maturation of all eukaryotic mRNAs except histone mRNAs. ...
The glycoprotein gp43 is an immunodominant antigen secreted by Paracoccidioides brasiliensis, the ag...
Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associa...
Abstract: Cardiolipins (CLs) are tetra-acylated diphosphatidylglycerols found in bacteria, yeast, pl...