Add to ORKGBACKGROUND: Identification of novel biomarkers could provide prognostic information and improve risk stratification in patients with aortic stenosis (AS). YKL-40 (chitinase-3-like protein 1), a protein involved in atherogenesis, is upregulated in human calcific aortic valves. We hypothesized that circulating YKL-40 would be elevated and associated with the degree of AS severity and outcome in patients with symptomatic AS. METHODS: Plasma YKL-40 was analyzed in 2 AS populations, one severe AS (n=572) with outcome measures and one with mixed severity (n=67). YKL-40 expression in calcified valves and in an experimental pressure overload model was assessed. RESULTS: We found (1) patients with AS had upregulated circulating YKL-40 compared with ...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Abstract Background Calcific aortic stenosis (CAS) is the most common heart valve disease in the eld...
Background: Identification of novel biomarkers could provide prognostic information and improve risk...
Background: Calcific aortic valve stenosis (CAVS) is seen in a large proportion of individuals over ...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Lipoprotein(a) (Lp(a)) is one of the most important risk factors for the development of calcific aor...
The global incidence of calcific aortic stenosis (CAS) is increasing owing, in part, to a growing el...
Objective: It has been suggested that atherosclerotic mechanisms are involved in the pathogenesis o...
Background and Aim. Degenerative Aortic Stenosis (DAS) is a common disease that causes substantial m...
Background-—YKL-40, encoded by the chitinase 3-like 1 (CHI3L1) gene, is a chitinase-like protein inv...
Introduction Atherosclerotic coronary artery disease is considered to be the most common cause of my...
BackgroundCalcific aortic stenosis (CAS) is seen in a large proportion of individuals after 60 years...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Abstract Background Calcific aortic stenosis (CAS) is the most common heart valve disease in the eld...
Background: Identification of novel biomarkers could provide prognostic information and improve risk...
Background: Calcific aortic valve stenosis (CAVS) is seen in a large proportion of individuals over ...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Background: Aortic valve stenosis (AS) is the most common indication for cardiac valve surgery; untr...
Lipoprotein(a) (Lp(a)) is one of the most important risk factors for the development of calcific aor...
The global incidence of calcific aortic stenosis (CAS) is increasing owing, in part, to a growing el...
Objective: It has been suggested that atherosclerotic mechanisms are involved in the pathogenesis o...
Background and Aim. Degenerative Aortic Stenosis (DAS) is a common disease that causes substantial m...
Background-—YKL-40, encoded by the chitinase 3-like 1 (CHI3L1) gene, is a chitinase-like protein inv...
Introduction Atherosclerotic coronary artery disease is considered to be the most common cause of my...
BackgroundCalcific aortic stenosis (CAS) is seen in a large proportion of individuals after 60 years...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Background— Calcific aortic valve stenosis (AS) is a major societal and economic burden that is risi...
Abstract Background Calcific aortic stenosis (CAS) is the most common heart valve disease in the eld...