The Effect of Including Bone in DIXON-based Attenuation Correction for 18F-fluciclovine PET/MRI of Prostate Cancer

The objective of this study was to evaluate the effect of including bone in DIXON-based attenuation correction for 18F-fluciclovine Positron Emission Tomography (PET) / Magnetic Resonance Imaging (MRI) of primary and recurrent prostate cancer. Methods:18F-fluciclovine PET data from two PET/MRI studies - one for staging of high-risk prostate cancer (28 patients) and one for diagnosis of recurrent prostate cancer (81 patients) - were reconstructed with a 4-compartment (reference) and 5-compartment attenuation map. In the latter, continuous linear attenuation coefficients for bone were included by co-registration with an atlas. The maximum and mean 50% isocontour standardized uptake values (SUVmax and SUViso, respectively) of primary, locally recurrent, and metastatic lesions were compared between the two reconstruction methods using linear mixed-effects models. In addition, mean SUVs were obtained from bone marrow in the third lumbar vertebra (L3) to investigate the effect of including bone attenuation on lesion-to-bone marrow SUV ratios (SUVRmax and SUVRiso; recurrence study only). The 5-compartment attenuation maps were visually compared to the in-phase DIXON MR images for evaluation of bone registration errors near the lesions. P-values < 0.05 were considered significant. Results: Sixty-two (62) lesions from 39 patients were evaluated. Bone registration errors were found near 19 (31%) of these lesions. In the remaining 8 primary prostate tumors, 7 locally recurrent lesions, and 28 lymph node metastases without bone registration errors, using the 5-compartment attenuation map was associated with small but significant increases in SUVmax [2.5%; 95% confidence interval (CI) 2.0%-3.0%; p<0.001] and SUViso (2.5%; 95% CI 1.9%-3.0%; p