Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial

Hals, Ingrid Kathrin
Fleiner, Hanne Fiskvik
Reimers, Nina
Astor, Marianne
Filipsson, Karin
Ma, Zuheng
Grill, Valdemar Erik Robert
Björklund, Anneli

Publication date

January 2019

Publisher

Royal College of Obstetricians & Gynaecologists (RCOG)

Abstract

Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor sitagliptin. Research design and methods We included 64 glutamic acid decarboxylase (GAD) antibody‐positive individuals, who were diagnosed with diabetes <3 years before the study, aged 30 to 70 years, and without clinical need for insulin treatment. We stratified participants by age and body mass index (BMI) and evaluated β‐cell function by GSCT after a 48‐hour temporary withdrawal of study medication. Results Age at randomization (mean 53 years), BMI (mean 27 kg/m2) and metabolic markers were similar between treatment arm...

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Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial

Hals, Ingrid Kathrin
Fleiner, Hanne Fiskvik
Reimers, Nina
Astor, Marianne
Filipsson, Karin
Ma, Zuheng
Grill, Valdemar Erik Robert
Björklund, Anneli

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Publication date

January 2019

Publisher

Royal College of Obstetricians & Gynaecologists (RCOG)

Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial

Abstract

Extracted data

Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial

Abstract

Extracted data

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