Toll-like receptors (TLRs) are an important part of the body's danger response system and crucial for initiating inflammation in response to cellular stress, tissue damage, and infections. Proper placental development is sensitive to inflammatory activation, and a role for TLRs in trophoblast immune activation has been suggested, but no overall examination has been performed in primary trophoblasts of early pregnancy. This study aimed to broadly examine cell surface and endosomal TLR gene expression and activation in first-trimester trophoblasts. Gene expression of all ten TLRs was examined by quantitative RT-PCR (RT-qPCR) in primary first-trimester trophoblasts (n = 6) and the trophoblast cell line BeWo, and cytokine responses to TLR ligan...
Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause o...
Introduction: Preeclampsia (PE) is characterized by an exaggerated systemic inflammatory response (...
Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, b...
Inflammatory processes are involved in the initiation and maintenance of labor, suggesting that toll...
Inflammatory processes are involved in the initiation and maintenance of labor, suggesting that Toll...
Objective. Toll-like receptor 4 (TLR4) is a key component of the innate arm of the immune system tha...
Toll-like receptors (TLRs) recognize conserved sequences on the surface of pathogens and trigger eff...
The role of viral infections in adverse pregnancy outcomes has gained interest in recent years. Inna...
Toll like receptors (TLR) have emerged as key upstream mediators of inflammation at many tiss...
Objective: The placenta constitutes a physical and immunological barrier against infectious agents. ...
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal ...
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal ...
An inflammatory response is instrumental in the physiological process of parturition but the upstrea...
INTRODUCTION: Toll-like receptor (TLR) activity within gestation-associated tissues might have a rol...
Toll-like receptors (TLRs) belong to a family of pathogen recognition receptors and play critical ro...
Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause o...
Introduction: Preeclampsia (PE) is characterized by an exaggerated systemic inflammatory response (...
Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, b...
Inflammatory processes are involved in the initiation and maintenance of labor, suggesting that toll...
Inflammatory processes are involved in the initiation and maintenance of labor, suggesting that Toll...
Objective. Toll-like receptor 4 (TLR4) is a key component of the innate arm of the immune system tha...
Toll-like receptors (TLRs) recognize conserved sequences on the surface of pathogens and trigger eff...
The role of viral infections in adverse pregnancy outcomes has gained interest in recent years. Inna...
Toll like receptors (TLR) have emerged as key upstream mediators of inflammation at many tiss...
Objective: The placenta constitutes a physical and immunological barrier against infectious agents. ...
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal ...
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal ...
An inflammatory response is instrumental in the physiological process of parturition but the upstrea...
INTRODUCTION: Toll-like receptor (TLR) activity within gestation-associated tissues might have a rol...
Toll-like receptors (TLRs) belong to a family of pathogen recognition receptors and play critical ro...
Histological chorioamnionitis (HCA) is an established marker of ascending infection, a major cause o...
Introduction: Preeclampsia (PE) is characterized by an exaggerated systemic inflammatory response (...
Toll plays an important role in innate immunity and embryonic development in lower-ranked animals, b...