Inactivating mutations of axis inhibition protein 1 (AXIN1), a negative regulator of the Wnt/beta-Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting approximately 10% of cases. In the present manuscript, we sought to define the genetic crosstalk between Axin1 mutants and Wnt/beta-catenin as well as Notch signaling cascades along hepatocarcinogenesis. We discovered that c-MET activation and AXIN1 mutations occur concomitantly in ~3%-5% of human HCC samples. Subsequently, we generated a murine HCC model by means of CRISPR/Cas9-based gene deletion of Axin1 (sgAxin1) in combination with transposon-based expression of c-Met in the mouse liver (c-Met/sgAxin1). Global gene expression analysis of...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
Hepatocellular carcinoma (HCC) and hepatoblastoma are the major types of primary liver cancer in adu...
AbstractBackground: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is...
International audienceBackground & aims - The Wnt/β-catenin pathway is the most frequently deregulat...
International audienceBackground & aims - The Wnt/β-catenin pathway is the most frequently deregulat...
BACKGROUND & AIMS: Mutations in components of the Wnt signaling pathway, including β-catenin and AXI...
BACKGROUND & AIMS: Mutations in components of the Wnt signaling pathway, including β-catenin and AXI...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
AXIN1 mutations are observed in 8–10% of hepatocellular carcinomas (HCCs) and originally were consid...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
textabstractAs one of the critical contributing factors to hepatocellular carcinoma (HCC) growth, ab...
Hepatocellular carcinoma (HCC) is the most frequent primitive liver cancer and represents the second...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
Hepatocellular carcinoma (HCC) and hepatoblastoma are the major types of primary liver cancer in adu...
AbstractBackground: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is...
International audienceBackground & aims - The Wnt/β-catenin pathway is the most frequently deregulat...
International audienceBackground & aims - The Wnt/β-catenin pathway is the most frequently deregulat...
BACKGROUND & AIMS: Mutations in components of the Wnt signaling pathway, including β-catenin and AXI...
BACKGROUND & AIMS: Mutations in components of the Wnt signaling pathway, including β-catenin and AXI...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
Background & Aims: Mutations in components of the Wnt signaling pathway, including β-catenin and AX...
AXIN1 mutations are observed in 8–10% of hepatocellular carcinomas (HCCs) and originally were consid...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
textabstractAs one of the critical contributing factors to hepatocellular carcinoma (HCC) growth, ab...
Hepatocellular carcinoma (HCC) is the most frequent primitive liver cancer and represents the second...
Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular c...
Hepatocellular carcinoma (HCC) and hepatoblastoma are the major types of primary liver cancer in adu...
AbstractBackground: Inactivation of the adenomatous polyposis coli (APC) tumor suppressor protein is...