Investigating the molecular basis of concussion using whole exome sequencing and bioinformatics

This thesis investigated the genetic influences of concussion development and outcomes. People react differently to similar head trauma; some may recover within a few weeks and some may develop long term symptoms for months or years. This thesis used a combination of genetic sequencing methods and machine learning to create pilot models for predicting these outcomes. The long-term goal of this work will allow for personalised treatments in the wake of concussion, tailored rest recommendations, as well as potential new drugs to help with management