Formulation, design, optimization and evaluation of cimetidine floating tablets by using 32 factorial design

The present study was aimed to formulate and evaluate floating tablets of Cimetidine which is a histamine H2 receptor antagonist in increasing usage in the medical management of peptic ulcer. In this study, excipients like HPMC K4M ,HPMC K100M were used as polymers and sodium bi- carbonate were incorporated in 9 different  concentrations (F1-F9) along  with other excipients.to formulate floating tablets. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and stability studies.The 32 Factorial design experiments helps the investigator in resource management and economy. The dissolution profile of F2 was observed to be better than other formulations. Trial-F2 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 98 % at the end of 12th hour. Thus, it can be concluded that the floating drug delivery system of cimetidne using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time